Fig. 1

The differential expression genes in osteosarcoma vs. normal control samples identified based on GEO datasets

From GEO datasets (A) GSE12865, (B) GSE16088, (C) GSE28424 and (D) GSE42352, the up-regulated (right-sided) and down-regulated (left sided) differential expression genes in osteosarcoma comparing to control samples were identified and classified into four groups based on difference level as: <2 fold genes(orange-colored spots), 2 ~ 4 fold genes (red-colored spots), 4 ~ 8 fold genes (green-colored spots) and > 8 fold genes (black-colored spots). (E) The intersection of all the differential expression genes in four GEO profiles. (F) The intersection of > 8 fold group of genes in four GEO profiles, the genes shared in at least two profiled were mainly focused for deeper analysis