Fig. 3
Construction of PPI network of > 8 fold genes and function modules analysis
The PPI network of 67 > 8 fold genes which were shared in at least 2 GEO profiles and three genes modules were identified based on the net work (three red circles and each represents one gene module). The cyan lines between genes represent interaction predicted by known databases, light purple lines represent experimentally validated interactions, green lines mean neighborhood genes, red lines represent gene fusions, black lines represent genes with co-expression, meanwhile, the azure lines represent homology proteins. (B, C, D) The diagrammatic sketch (left diagram) and the detailed information (right table) including the module score, module description and detailed involving genes of three main modules in the PPI network. (*The 22 genes in second module were mainly focused for deeper analysis)