Skip to main content

Table 3 Model discrimination assessed for combinations of polygenic risk score, family history of CRC and carrier

From: Clinically relevant combined effect of polygenic background, rare pathogenic germline variants, and family history on colorectal cancer incidence

 

AUC (C.I 95%)

C-index

Nagelkerke's Pseudo-R2

PRS + FH + carrier

0.704 (0.68–0.73)

0.657

0.055

PRS + FH

0.698 (0.67–0.72)

0.652

0.052

PRS + carrier

0.693 (0.66–0.71)

0.646

0.051

PRS

0.688 (0.66–0.71)

0.640

0.049

FH + carrier

0.660 (0.64–0.68)

0.580

0.032

FH

0.654 (0.63–0.68)

0.574

0.031

Carrier

0.646 (0.62–0.67)

0.556

0.030

Back to article page

BMC Medical Genomics

ISSN: 1755-8794

Contact us