Fig. 6

DE and GSEA statistics for genes and gene sets associated with APOE ε4 and TMEM106B risk alleles. Genes associated with risk alleles in both sample groups were largely disjoint, and gene sets associated with APOE and TMEM106B risk alleles were primarily found in CTE-L + RHI and CTE-H, respectively. A, B Venn diagram of nominally significant (p-value < 0.05) gene overlap and scatterplot of L2FC of CTE-L + RHI versus CTE-H sample groups for APOE (A) and TMEM106B risk allele (B), respectively. C, D Venn diagram of nominally significant (p-value < 0.05) gene overlap and scatterplot of L2FC of APOE ε4 versus TMEM106B risk allele forCTE-L + RHI (C) and CTE-H (D), respectively. E NES heatmap of GO terms significant at FDR < 0.1 in at least one condition. Bars on left of the heatmap indicate significance of corresponding NES in the heatmap columns respectively, GO IDs that were significant at FDR < 0.1 is in red. F, G GO pathways that were FDR < 0.1 grouped by category. Values left of zero corresponds to number of significant pathways with negative NES. Values right of zero corresponds to number of significant pathways with positive NES