Skip to main content
Fig. 5 | BMC Medical Genomics

Fig. 5

From: Identifying potential biomarkers for the diagnosis and treatment of IgA nephropathy based on bioinformatics analysis

Fig. 5

PPI network of DEGs, five cluster modules extracted by MCODE and identification of hub genes. (A) A network of PPI among the DEGs was established on STRING database. The highly expressed genes are illustrated by the red ellipses and lowly expressed genes by the green diamonds. Nodes represent genes, while edges represent protein-protein interaction. (B) Cluster 1 (MCODE score = 7). (C) Cluster 2 (MCODE score = 6.667). (D) Cluster 3 (MCODE score = 3). (E) Cluster 4 (MCODE score = 3). (F) Cluster 5 (MCODE score = 3). (G) Ten crucial genes were screened through MCC algorithm in Cytoscape. The higher the score, the deeper the color. (H) The GO terms enrichment analysis of the ten identified hub genes. (I) KEGG pathways analysis of identified ten hub genes. DEG: differentially expressed gene; PPI: protein-protein interaction

Back to article page

BMC Medical Genomics

ISSN: 1755-8794

Contact us