AVPR2 is a potential prognostic biomarker and correlated with immune infiltration in head and neck squamous cell carcinoma

Table 3 Correlation between AVPR2 and the list of signature genes of all immune cells analyzed by GEPIA2

Description	Signature genes list	Tumor		Normal
Description	Signature genes list	Cor	P value	Cor	P value
Neutrophols	CCR7 ITGAM CEACAM8	0.32	***	0.23	0.13
Natural killer cell	KIR3DL3 KIR2DS4 KIR3DL2 KIR3DL1 KIR2DL4 KIR2DL3 KIR2DL1	0.096	0.029	− 0.12	0.44
Monocyte	CSF1R CD86	0.21	***	0.14	0.36
M1 Macrophage	NOS2 PTGS2 IRF5	0.07	0.11	− 0.11	0.48
M2 Macrophage	CD163 MS4A4A VSIG4	0.2	***	0.52	**
TAM	CCL2 IL10 CD68	0.24	***	0.33	0.027
Dendritic cell	CD1C HLA-DPB1 HLA-DPA1 HLA-DRA ITGAX HLA-DQB1 NRP1	0.26	***	0.12	0.44
B cell	CD19 CD79A	0.3	***	− 0.12	0.42
T cell (general)	CD3E CD2 CD3D	0.26	***	− 0.24	0.12
CD8+ T cell	CD8B CD8A	0.2	***	− 0.21	0.17
Th1	TBX21 STAT4 STAT1 IFNG TNF	0.15	**	− 0.099	0.52
Th2	Th2 Th2 Th2 Th2	0.23	***	0.055	0.72
Th17	STAT3 IL17A	0.15	**	− 0.18	0.23
Treg	FOXP3 STAT5B CCR8 TGFB1	0.22	***	0.051	0.74
Tfh	BCL6 IL21	0.19	***	0.11	0.47
T cell exhaustion	PDCD1 CTLA4 HAVCR2 LAG3 GZMB	0.16	**	− 0.097	0.53

Tumor, correlation analysis in tumor tissue of TCGA. Normal, correlation analysis in normal tissue of TCGA
*P < 0.01; **P < 0.001; ***P < 0.0001

ISSN: 1755-8794