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Table 6 Details of NIHF with unknown etiology

From: Genetic disorders and pregnancy outcomes of non-immune hydrops fetalis in a tertiary referral center

Case NO.

GA at diagnosis (weeks)

Maternal age

Ultrasound Imaging

Karyotype

CMA Results

Outcomes

84

12

30

GSE, NCH

46, XX

N

TOP

85

12

35

GSE, INT

46, XX

N

TOP

86

12

31

GSE, gastroschisis

46, XY

N

TOP

87

12

29

GSE

46, XX

N

IUFD

88

12

28

GSE, INT, CVM

46, XX

NA

TOP

89

13

29

GSE, INT, cleft lip and palate

46, XX

NA

TOP

90

13

35

GSE, INT, bilateral pleural effusion

46, XX

N

PA, IUFD

91

14

27

ascites, pericardial effusion, CVM,

46, XY

N

TOP

92

15

19

GSE

46, XX

N

PA, IUFD

93

15

25

GSE, NCH

46, XY

N

TOP

94

21

35

GSE, NCH, CVM, placental thickening

46, XX

N

TOP

95

22

32

GSE, pleural effusion, ascites, cleft lip and palate, arrhythmias

46, XX

N

TOP

96

23

26

ascites, pericardial effusion, FGR, placental thickening, cardiomegaly, pulmonary dysplasia

46, XY

N

TOP

97

23

28

ascites, pericardial effusion, cardiomegaly, sacrococcygeal region teratoma, polyhydramnios

46, XY

N

TOP

98

23

30

bilateral pleural effusion, CVM

46, XX

N

TOP

99

23

26

bilateral pleural effusion

46, XX

N

RA, term(38W), CS, drainage,

ND at 4-year follow-up

100

23

33

GSE, NCH, CVM

46, XX

NA

TOP

101

24

32

GSE, FGR

46, XY

N

PA, IUFD

102

24

34

ascites, pericardial effusion, cardiomegaly, polyhydramnios

46, XX

N

PA, IUFD

103

24

29

pericardial effusion, local skin edema

46, XY

N

RA ,Term(39W),CS, ascites absorpted ,

ND at 4-year follow-up

104

25

36

GSE, NCH

46, XY

N

PA, IUFD

105

25

26

ascites, pleural effusion

46, XX

N

TOP

106

26

25

GSE, ascites, pleural effusion, tachyarrhythmias

46, XY

N

PA, IUFD

107

27

26

GSE, polyhydramnios, cardiomegaly

46, XY

N

TOP

108

27

36

pleural effusion, local skin edema, NCH

46, XX

N

TOP

109

28

30

ascites, pericardial effusion, CVM, placental thickening, local skin edema

46, XY

N

TOP

110

28

36

ascites, bilateral pleural effusion

46, XY

N

PA, IUFD

111

28

28

GSE

46, XY

N

TOP

112

28

27

ascites, local skin edema

46, XX

NA

TOP

113

31

32

bilateral pleural effusion, local skin edema

46, XY

N

RA ,Term(41+4w),Natural delivery,edema absorpted ,

ND at 3-year follow up

114

31

24

ascites, bilateral pleural effusion, CVM

46, XX

N

TOP

115

31

33

ascites, pleural effusion

46, XY

N

TOP

116

32

36

GSE

46, XX

N

PA, Preterm(35+3w),Natural delivery, END

117

33

28

ascites, local skin edema

46, XY

NA

RA ,Term(37 W),Natural delivery, ascites absorpted ,

ND at 4-year follow up

118

33

26

ascites, pericardial effusion, cardiomegaly, polyhydramnios

46, XY

N

TOP

119

33

38

bilateral pleural effusion, polyhydramnios

46, XX

NA

PA, preterm(34W), Natural delivery, END

120

35

27

ascites, pleural effusion

46, XY

N

RA, preterm(36W), CS, drainage,

ND at 4-year follow up

121

36

27

GSE

46, XY

N

TOP

122

36

24

GSE

46, XY

NA

PA, preterm(36W), Natural delivery, END

123

36

32

bilateral pleural effusion, polyhydramnios

46, XY

N

RA ,preterm(36+5W),CS,drainage,

ND at 3-year follow up

124

38

19

pericardial effusion, local skin edema

46, XX

NA

RA, Term(39+1W),CS, ascites absorbed ,

ND at 3-year follow up

125

24

23

ascites, pericardial effusion, placental thickening ,cardiomegaly ,MCA PSV >1.55MoM

46, XX

N

Lost to follow up

126

28

39

bilateral pleural effusion, polyhydramnios, CVM

46, XX

N

Lost to follow up

127

28

33

ascites, pericardial effusion, placental thickening, cardiomegaly

46, XY

NA

Lost to follow up

128

35

34

bilateral pleural effusion

46, XY

N

Lost to follow up

129

37

39

GSE, ascites, pleural effusion, polyhydramnios, CVM

46, XY

NA

Lost to follow up

  1. Abbreviations: GA, gestational age; TOP, termination of pregnancy; IUFD, intrauterine fetal demise; INT, increased nuchal translucency;
  2. FGR, fetal growth retardation
  3. GSE, generalized skin edema; NCH, nuchal cystic hygroma; CVM, cardiovascular malformation
  4. CS, cesarean section
  5. ND, normal development
  6. RA, remission antenatal
  7. PA, progression antenatal
  8. N, normal
  9. NA, not available