Table 2 Univariate and multivariate Cox analysis of OS in TCGA-BRCA

Age

1082

  ≤ 60

601

Reference

  > 60

481

2.020 (1.465–2.784)

 < 0.001

3.154 (1.616–6.155)

 < 0.001

T stage

1079

 T1

276

Reference

 T2

629

1.332 (0.887–1.999)

0.166

1.013 (0.520–1.973)

0.970

 T3&T4

174

1.953 (1.221–3.123)

0.005

1.649 (0.683–3.982)

0.266

N stage

1063

 N0

514

Reference

 N1

357

1.956 (1.329–2.879)

 < 0.001

1.376 (0.702–2.697)

0.352

 N2

116

2.519 (1.482–4.281)

 < 0.001

2.985 (1.297–6.869)

0.010

 N3

76

4.188 (2.316–7.574)

 < 0.001

6.068 (2.364–15.573)

 < 0.001

M stage

922

 M0

902

Reference

 M1

20

4.254 (2.468–7.334)

 < 0.001

3.639 (1.152–11.498)

0.028

ER status

1032

 Negative

240

Reference

 Positive

792

0.712 (0.495–1.023)

0.066

0.469 (0.189–1.164)

0.102

PR status

1029

 Negative

342

Reference

 Positive

687

0.732 (0.523–1.024)

0.068

1.028 (0.440–2.403)

0.948

HER2 status

715

 Negative

558

Reference

 Positive

157

1.593 (0.973–2.609)

0.064

0.931 (0.476–1.821)

0.836

Menopause status

931

 Pre

229

Reference

 Post

702

2.165 (1.302–3.600)

0.003

2.083 (0.863–5.032)

0.103