Fig. 2

Volcano plot and heatmap of differential expression of GSE43292 (A, B), GSE97210 (C, D), and GSE100927 (E, F). In the volcano plot, the blue plots represent downregulated DEGs; the gray plots represent non-significant genes, and the red plots represent upregulated DEGs. The heatmap shows the two-way hierarchical clustering results of the top 50 ranked differential expression profiles and samples with adjusted P values. Each row in the heatmap represents a gene, and each column represents a sample. The color scale on the right side of the heatmap represents the homogenous expression value, ranging from blue (low expression) to red (high expression)