Table 2 List of the 10 most important small molecule compounds provided by CMap analysis based on robust DEGs
CMap name | Description | Target | Score |
|---|---|---|---|
KU-C103428N | CDC inhibitor | NFE2 | − 95.01 |
Desoxypeganine | Acetylcholinesterase inhibitor | ACHE, MAOA | − 91.59 |
MBCQ | Phosphodiesterase inhibitor | PDE5A | − 90.16 |
Phylloquinone | Vitamin K | BGLAP, GGCX | − 90.11 |
Gossypol | BCL inhibitor | BCL2, BCL2L1, MCL1, BCL2L2, CTGF, EGF | − 89.72 |
Kavain | Calcium channel modulator | MTOR | − 89.71 |
Flubendazole | Tubulin inhibitor | TUBB | − 86.28 |
VX-702 | p38 MAPK inhibitor | MAPK14, MAPK11, MAPK12 | − 85.43 |
Palonosetron | Serotonin receptor antagonist | HTR3A | − 83.07 |
Linsitinib | IGF-1 inhibitor | IGF1R, INSR, INSRR | − 81.75 |