Table 3 Allele and genotype frequencies of PADI4 gene rs11203367 and rs1748033 SNPs in RA patients and healthy controls and corresponding association analyses

T

223 (44.6%)

216 (43.2%)

C

277 (55.4%)

284 (56.8%)

TT

51 (20.4%)

48 (19.2%)

TC

121 (48.4%)

120 (48%)

CC

78 (31.2%)

82 (32.8%)

HWE for controls = 0.729

Association Test

Model

OR

95% CI

P value

Allele

T vs. C

1.05

0.82–1.35

0.6541

Codominant

TT vs. CC

1.11

0.67–1.84

0.6652

Codominant

TC vs. CC

1.06

0.71–1.58

0.7751

Dominant

TT + TC vs. CC

1.07

0.73–1.56

0.7015

Recessive

TT vs. TC + CC

1.07

0.69–1.67

0.7364

rs1748033

T

211 (42.4%)

158 (31.6%)

C

289 (57.8%)

342 (68.4%)

TT

42 (16.8%)

21 (8.4%)

TC

127 (50.8%)

116 (46.4%)

CC

81 (32.4%)

113 (45.2%)

HWE for controls = 0.246

Association Test

Model

OR

95% CI

P value

Allele

T vs. C

1.58

1.21–2.04

0.0005

Codominant

TT vs. CC

2.79

1.53–5.06

0.0007

Codominant

TC vs. CC

1.52

1.04–2.23

0.0291

Dominant

TT + TC vs. CC

1.72

1.19–2.47

0.0034

Recessive

TT vs. TC + CC

2.19

1.25–3.82

0.0057