Table 5 Association of PADI4 gene rs11203367 and rs1748033 SNPs with clinical manifestations of RA patients

PADI4 mRNA expression

2.65 ± 1.33

2.78 ± 1.16

2.60 ± 1.32

0.416

Age

50.31 ± 11.24

55.23 ± 10.26

53.56 ± 11.56

0.216

BMI

30.2 ± 5.12

28.41 ± 4.12

29.25 ± 4.89

0.455

Anti-CCP

56.31 ± 41.49

57.56 ± 42.54

58.21 ± 41.41

0.208

RF

41.33 ± 31.64

44.34 ± 33.25

39.23 ± 31.45

0.190

ESR

20.15 ± 18.21

22.3 ± 18.45

21.68 ± 18.90

0.244

CRP

3.41 ± 2.45

3.58 ± 2.55

2.41 ± 2.61

0.416

DAS28

4.89 ± 1.01

3.89 ± 1.16

4.7 ± 1.18

0.129

rs1748033 (TT)

rs1748033 (TC)

rs1748033 (CC)

PADI4 mRNA expression

2.81 ± 1.18

2.61 ± 1.27

2.66 ± 1.38

0.311

Age

51.48 ± 10.24

52.89 ± 10.47

53.74 ± 10.25

0.657

BMI

28.95 ± 5.01

29.51 ± 5.18

29.84 ± 5.11

0.587

Anti-CCP

64.54 ± 45.25

55.78 ± 40.44

54.73 ± 38.25

0.041

RF

44.07 ± 34.15

41.28 ± 30.81

40.18 ± 30.07

0.077

ESR

21.14 ± 18.78

21.45 ± 17.91

21.20 ± 18.12

0.619

CRP

3.14 ± 2.23

3.61 ± 2.24

2.51 ± 2.67

0.358

DAS28

6.95 ± 1.74

4.41 ± 0.88

3.10 ± 0.46

0.034