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Fig. 3 | BMC Medical Genomics

Fig. 3

From: Single-cell RNA sequencing reveals sexual diversity in the human bladder and its prospective impacts on bladder cancer and urinary tract infection

Fig. 3

Sex-related diversity of fibroblasts in the human bladder. (A) Boxplots showing that seven collagen genes are upregulated in the advanced stages of BCa. (B) Heatmap demonstrating representative GO pathways of the fibroblasts of females and males based on a DEG analysis between females and males. (C) Violin plots showing that 12 ECM genes are predominantly expressed in female fibroblasts. (D-E) Pseudotime trajectory analysis of seven BCa-related ECM genes in fibroblasts from females (D) and males (E). The results show that the relative expression levels of these seven collagen genes were higher in female fibroblasts than in male fibroblasts during the process of fibroblast differentiation. (F) SCENIC analysis showing that most transcription factors of seven BCa-related ECM genes exhibit higher activity in female fibroblasts

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BMC Medical Genomics

ISSN: 1755-8794

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