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Table 3 The genotype distribution and allele frequency of VDR SNPs in the fertile and PCOS groups and the PCOS phenotype groups, 1ry infertility and 2nd infertility

From: Vitamin D receptor gene polymorphism and polycystic ovary syndrome susceptibility

SNP (AJ/AI)

Genotypes M/H/N

MAF

HW

GMAF

Fertile (207)

PCOS (185)

PCOS phenotypes

Total

(392)

1ry infertility

2nd infertility

A (88)

C (41)

D (56)

q 2

P

rs11568820 (C/T)

154/45/8

(0.15)

63/71/51

(0.47)

31/30/27

(0.48)

14/16/11

(0.46)

18/25/13

(0.45)

217/116/59

31/41/26

32/30/25

0.30

3.76

0.052

0.46

rs4516035 (C/T)

149/49/9

(0.16)

120/27/38

(0.28)

54/16/18

(0.30)

26/7/8

(0.28)

40/4/12

(0.25)

269/76/47

60/20/18

60/7/20

0.22

3.36

0.066

0.18

rs2228570 (FokI) (C/T)

146/54/7

(0.16)

110/48/27

(0.28)

56/22/10

(0.24)

21/12/8

(0.30)

33/14/9

(0.29)

256/102/34

56/29/13

51/22/14

0.22

0.52

0.473

0.33

rs3782905 (C/G)

154/48/5

(0.14)

104/55/26

(0.29)

53/26/9

(0.25)

22/11/8

(0.33)

29/18/9

(0.32)

258/103/31

53/33/12

51/22/14

0.21

0.29

0.532

0.24

rs2107301 (C/T)

165/37/5

(0.11)

108/58/19

(0.26)

48/29/11

(0.29)

24/15/2

(0.23)

36/14/6

(0.23)

273/95/24

60/29/9

48/29/10

0.18

2.59

0.107

0.34

rs1544410 (BsmI) (G/A)

153/47/7

(0.15)

104/51/30

(0.30)

46/28/14

(0.32)

25/9/7

(0.28)

33/14/9

(0.29)

257/98/37

51/28/19

53/23/11

0.22

1.92

0.165

0.30

rs7975232 (ApaI) (A/C)

133/60/14 (0.21)

99/54/32

(0.32)

52/23/13

(0.28)

18/14/9

(0.39)

29/17/10

(0.33)

232/114/46

49/30/19

50/24/13

0.26

3.72

0.052

0.45

rs731236 (TaqI) (T/C)

164/38/5

(0.12)

102/48/35

(0.32)

44/28/16

(0.34)

23/9/9

(0.33)

35/11/10

(0.28)

266/86/40

53/25/20

49/23/15

0.21

2.26

0.133

0.28

rs739837 (T/G)

159/42/6

(0.13)

107/51/27

(0.28)

50/24/14

(0.30)

21/12/8

(0.34)

36/15/5

(0.22)

266/93/33

59/25/14

52/22/13

0.20

2.31

0.129

0.49

  1. SNP, single-nucleotide polymorphism; AJ, major allele; AI, minor allele; M/H/N, number of homozygous individual carriage major alleles/number of heterozygotes/number of minor allele homozygotes; PCOS, polycystic ovary syndrome; MAF, minor allele frequency; HW, Hardy–Weinberg equilibrium; P, probability < 0.05; GMAF, global minor allele frequency.