Table 1 Mendelian randomization results and heterogeneity analysis for effect of genetically predicted fatty acid metabolites on asthma

Ratio of bis-allylic groups to double bonds

IVW

35

1.05 (1.03–1.08)

2.09 × 10^–4

47.24

28.03%

0.07

Weighted Median

35

1.10 (1.06–1.14)

1.67 × 10^–7

–

–

–

MR-Egger

35

1.09 (1.04–1.14)

5.75 × 10^–4

42.81

22.91%

0.12

0.07

Ratio of bis-allylic groups to total fatty acids

IVW

34

1.06 (1.03–1.10)

3.3 × 10^–4

71.54

53.87%

8.11 × 10^–5

Weighted Median

34

1.12 (1.07–1.16)

1.52 × 10^–8

MR-Egger

34

1.07 (1.02–1.13)

1.6 × 10^–2

71.28

55.11%

1.15 × 10^–4

0.73

Average number of methylene groups in a fatty acid

IVW

30

0.92 (0.88–0.96)

4.69 × 10^–5

47.46

38.90%

1.67 × 10^–2

Weighted Median

30

0.93 (0.87–0.98)

1.12 × 10^–2

MR-Egger

30

0.86 (0.81–0.93)

2.69 × 10^–4

41.36

32.30%

4.97 × 10^–2

0.05