Table 2 Mendelian randomization results for effect of genetic liability to asthma on fatty acid metabolites
Outcome | Exposure | Method | P value | Beta | OR |
|---|---|---|---|---|---|
Ratio of bisallylic groups to double bonds | Asthma | MR Egger | 0.45 | − 0.2 (− 0.71, 0.31) | 0.82 (0.49, 1.37) |
Weighted median | 0.83 | 0.01 (− 0.07, 0.09) | 1.01 (0.93, 1.09) | ||
Inverse variance weighted | 0.38 | 0.09 (− 0.11, 0.28) | 1.09 (0.9, 1.33) | ||
Ratio of bisallylic groups to total fatty acids | Asthma | MR Egger | 0.53 | − 0.14 (− 0.57, 0.29) | 0,87 (0.56, 1.34) |
Weighted median | 0.49 | 0.03 (− 0.05, 0.12) | 1.03 (0.95, 1.12) | ||
Inverse variance weighted | 0.43 | 0.07 (− 0.1, 0.23) | 1.07 (0.90, 1.26) | ||
Average number of methylene groups in a fatty acid chain | Asthma | MR Egger | 0.72 | 0.05 (− 0.23, 0.34) | 1.05 (0.79, 1.4) |
Weighted median | 0.79 | 0.01 (− 0.06, 0.08) | 1.01 (0.94, 1.08) | ||
Inverse variance weighted | 0.39 | − 0.05 (− 0.15, 0.06) | 0.95 (0.86, 1.06) |