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Fig. 1 | BMC Medical Genomics

Fig. 1

From: Genome-wide DNA methylation profiling of CD4+ T lymphocytes identifies differentially methylated loci associated with adult primary refractory immune thrombocytopenia

Fig. 1

Characteristics of differential DNA methylation sites. A: Distributions of CPG sites (CPG island: CG-rich regions, CpG island shore: 2 kb regions flanking a CpG island, CpG shelf: 2 kb region outside a CpG shore, open sea: other regions besides CpG islands, CpG shores, and CpG shelves). B: Distribution of CPG in gene region. C: Number of differentially methylated genes. D: Number of differentially methylated loci. E: Heat map of differentially methylated CPG sites (Each column is a sample and each row represents methylation level, red and blue indicates higher and lower methylation, respectively. The top color bar reflects the grouping of samples, and there exists a significant difference in DNA methylation between the two groups). F: Volcano plot of the differentially methylated loci (abscissa scale is DeltaBeta, ordinate scale is –log10 (P values), red dots signify hypermethylated regions and blue hypomethylated, and grey regions designate loci with no significant difference)

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BMC Medical Genomics

ISSN: 1755-8794

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