Fig. 10

Analysis of GLT8D1/2 methylation levels in gastric cancer based on the MethSurv database. (A, B) Heat map depicting clustering of the CpGs methylation levels within GLT8D1 (A) and GLT8D2 (B) in gastric cancer. Methylation levels (0 = fully unmethylated; 1 = fully methylated) are shown as a continuous variable from a blue to red color. Rows correspond to the CpGs, the columns correspond to the samples. (C, D) The Kaplan-Meier survival analysis of the promoter methylation of GLT8D1. (E-O) The Kaplan-Meier survival analysis of the promoter methylation of GLT8D2. The red and blue lines of Kaplan-Meier plots indicate higher (β > cut-off) and lower (β < cut-off) methylation patient groups, respectively, dichotomized according to the best cut-off point in MethSurv. HR, hazard ratio; LR, Log-likelihood ratio