Fig. 2

Forrest plot for causal associations of socioeconomic traits with FGP risk based on five UVMR methods. The forest plot suggests causal effect of genetical predisposition to lower EA on higher FGP risk based on IVW UVMR method. Inconsistently, the other five socioeconomic traits do not have any causal effect on FGP risk. Abbreviations: CI = confidence interval; EA = “educational attainment”; FGP = female genital prolapse; heavy physical work = “job involves heavy manual or physical work”; income = “average total household income before tax”; IVW = inverse-variance weighted; MR = Mendelian randomization; nSNP = number of single-nucleotide polymorphism; OR = odds ratio; pub or club = “leisure/social activities: pub or social club”; sports = “leisure/social activities: sports club or gym”; TDI = “Townsend deprivation index at recruitment”; UVMR = univariate Mendelian randomization; WM = weighted median