Fig. 3

Forrest plot for causal associations of socioeconomic traits with FGP risk based on IVW MVMR Model 1 and 2. The forest plot demonstrates that EA is independently and predominantly responsible for causal effects of socioeconomic traits on FGP risk after adjusting for heavy physical work, TDI, and pub or club (Model 1), or adjusting for heavy physical work, income, TDI, and sports (Model 2). Abbreviations: nSNP = number of single-nucleotide polymorphism; OR = odds ratio; CI = confidence interval; EA = educational attainment; FGP = female genital prolapse; heavy physical work = job involves heavy manual or physical work; income = average total household income before tax; IVW = inverse-variance weighted; MR = Mendelian randomization; MVMR = multivariable Mendelian randomization; pub or club = leisure/social activities: pub or social club; sports = leisure/social activities: sports club or gym; TDI = Townsend deprivation index at recruitment