Table 2 UVMR analyse for genetically causal associations of socioeconomic traits with FGP risk
Socioeconomic traits | nSNP | R2 (%) | F-statistic | IVW | WM | MR-Egger | Power(%) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
OR | 95% CI | p | OR | 95% CI | p | OR | 95% CI | p | |||||||
Educational attainment | 320 | 0.597 | 21.225 | 0.759 | 0.629–0.916 | 0.004 | 0.779 | 0.590–1.029 | 0.079 | 0.893 | 0.434–1.841 | 0.76 | 41 | ||
Job involves heavy manual or physical work | 15 | 0.07 | 12.326 | 1.518 | 0.779–2.956 | 0.22 | 1.053 | 0.434–2.551 | 0.910 | 1.524 | 0.049–47.149 | 0.814 | 22 | ||
Average total household income before tax | 32 | 0.115 | 14.311 | 1.257 | 0.775–2.037 | 0.354 | 1.485 | 0.844–2.615 | 0.17 | 1.304 | 0.127–13.389 | 0.825 | 32 | ||
PPRESSO adjustment | 31 | 0.111 | 14.251 | 1.402 | 0.898–2.189 | 0.137 | 1.538 | 0.850–2.781 | 0.155 | 0.912 | 0.109–7.642 | 0.933 | 21 | ||
Type of accommodation lived in: a flat, maisonette or apartment | 1 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | ||
Type of accommodation lived in: a house or bungalow | 1 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | ||
Townsend deprivation index at recruitment | 13 | 0.151 | 53.81 | 0.598 | 0.232–1.542 | 0.287 | 1.212 | 0.385–3.815 | 0.743 | 0.147 | 0.001–30.421 | 0.496 | 32 | ||
Leisure/social activities: pub or social club | 10 | 0.028 | 12.995 | 0.136 | 0.006–3.239 | 0.218 | 0.36 | 0.015–8.712 | 0.529 | 0.391 | 1.070 × 10− 6–1.430 × 105 | 0.889 | 33 | ||
PPRESSO adjustment | 8 | 0.02 | 11.757 | 0.524 | 0.023–11.765 | 0.684 | 1.004 | 0.038–26.615 | 0.998 | 0.015 | 0.182 × 10− 6–1.250 × 103 | 0.495 | 10 | ||
Leisure/social activities: sports club or gym | 7 | 0.041 | 27.238 | 1.753 | 0.053–58.028 | 0.753 | 9.512 | 0.228–396.676 | 0.237 | 0.835 | 0.408 × 10− 17–1.710 × 1017 | 0.993 | 25 | ||