Table 4 Causal effects of multiple socioeconomic traits on FGP risk based on IVW MVMR model

 EA

402

-0.248

0.091

0.842

0.744–0.953

0.006

 Heavy physical work

402

-0.047

0.165

0.968

0.774–1.211

0.774

 TDI

402

0.148

0.264

1.108

0.774–1.586

0.574

 Pub or Club

402

-0.92

0.624

0.529

0.226–1.234

0.141

Model 2

 EA

408

-0.223

0.089

0.857

0.759–0.967

0.012

 Heavy Physical Work

408

-0.327

0.232

0.797

0.582–1.093

0.159

 Income

408

-0.341

0.225

0.789

0.582–1.072

0.13

 TDI

408

-0.193

0.303

0.875

0.580–1.320

0.524

 Sports

408

0.127

0.744

1.092

0.397–3.001

0.864

Abbreviations: FGP = female genital prolapse; IVW = inverse-variance weighted; MVMR = Multivariable Mendelian randomization; SE = standard error; OR = odds ratio; CI = confidence interval; EA = Educational attainment; Heavy physical work = job involves heavy manual or physical work; Average total household income before tax; nSNP = number of single-nucleotide polymorphism; Pub or club = Leisure/social activities: pub or social club; Sports = Leisure/social activities: sports club or gym; TDI = Townsend deprivation index at recruitment.