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Table 1 Overview of 48 patients and their family’s cancer history

From: Detection of germline variants with pathogenic potential in 48 patients with familial colorectal cancer by using whole exome sequencing

ID (Fid)

CRC: Age of detection and diagnosis

Other cancers and age of detection

Family cancer history: Numbers of affected members and cancer types

S.13 (F.1)

Y (50)

-

4 CRC, 1 stomach, 1 melanoma

S.46 (F.1)

Y (46)

Lung (51)

S.34 (F.2)

Y (48)

-

3 CRC, 2 melanoma, 1 ovarian, 1 leukaemia, 1lung, 1 kidney, 4 breast, 1 uterine

S.36 (F.2)

N

Uterine (41)

S.47 (F.3)

Y (34)

Melanoma (32)

5 CRC, 2 melanoma, 3 breast,1 uterine, 2 kidney, 1 lung, 1 oesophagus, 1 bladder

S.48 (F.3)

N

Renal (53)

S.37 (F.4)

Y (38)

-

2 CRC, 1 stomach, 1 throat

S.41 (F.4)

Y (53)

-

S.23 (F.5)

Y (51)

-

4 CRC

S.25 (F.5)

Y (52)

-

S.44 (F.6)

Y (33)

Uterine (NA)

3 CRC

S.45 (F.6)

N

Uterine (59)

S.03 (F.7)

N

Ovarian (78)

1 CRC, 1 ovarian, 2 breast, 1 stomach, 1 renal, 1 liver

S.04 (F.7)

Y (31)

-

S.01 (F.8)

Y (64)

-

3 CRC, 1 breast, 1 kidney

S.02 (F.8)

Y (30 s)

Breast (30 & 70)

S.31

Y (57)

-

9 CRC

S.42

Y (12)

CRC (29)

-

S.19

Y (21)

CRC (40), non-hodgkin lymphoma (42)

-

S.27

N

Ureter (60)

6 CRC

S.18

Y (70)

-

5 CRC, 1 stomach, 1 lung, 1 cervical, 1 polyps

S.43

Y (51)

CRC (64)

5 CRC

S.38

Y (45)

-

5 CRC, 1 acute lymphoblastic leukaemia, 1 hodgkin lymphoma, 1 brain

S.06

Y (60)

Kidney (60), bladder (53)

5 CRC, 1 prostate

S.07

Y (50)

-

5 CRC, 1 uterine

S.24

Y (50)

-

5 CRC, 1 stomach

S.05

Y (64)

-

5 CRC, 1 breast, 1 jaw

S.12

Y (60)

-

4 CRC

S.15

Y (42)

-

4 CRC

S.21

N

Pancreas (62)

4 CRC

S.32

Y (58)

Pancreatic (60)

4 CRC, 3 unknown

S.40

Y (66)

Stomach (NA), kidney (NA)

4 CRC, 4 stomach, 1 brain, 4 eye, 2 lung

S.28

Y (57)

-

4 CRC, 1 kidney

S.17

Y (72)

Kidney (71)

4 CRC

S.08

Y (48)

-

4 CRC, 1 endometrial, 1 throat

S.29

Y (48)

Uterine (56)

3 CRC, 1 abdomen

S.10

Y (53)

Kidney (59)

3 CRC, 2 bladder, 1 lymphoma, 1 brain, 3 melanoma, 1 thyroid, 2 breast, 1 unknown

S.11

Y (60)

Bone (32), breast (57)

3 CRC

S.14

Y (52)

Breast (52)

3 CRC

S.35

Y (36)

Bladder (35), uterine (35)

2 CRC, 4 breast, 2 throat, 2 non-Hodgkin lymphoma

S.30

Y (68)

Ureter (79)

3 CRC, 1 prostate

S.22

Y (54)

CRC (55)

2 CRC, 2 unknown

S.20

Y (55)

Endometrial (41), breast (51)

3 CRC, 3 renal, 1 endometrial, 1 melanoma

S.09

Y (65)

Uterine (50)

2 CRC, 1 breast

S.16

Y (48)

CRC (67)

2 CRC, 1 stomach

S.33

Y (63)

Endometrial (29)

1 CRC, 1 leukaemia, 1 melanoma, 1 endometrial, 3 unknown

S.26

Y (65)

Endometrial (50)

1 Stomach, 1 throat

S.39

Y (77)

Renal (51), uterine (55)

1 CRC, 1 brain, 1 unknown

  1. Age is in years
  2. Abbreviations: ID Patient ID, Fid Family ID, CRC Colorectal cancer, NA Age not available