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Fig. 3 | BMC Medical Genomics

Fig. 3

From: LSM2 is associated with a poor prognosis and promotes cell proliferation, migration, and invasion in skin cutaneous melanoma

Fig. 3

DepMap screening of the LSM2 gene

A. Enriched lineages of LSM2. Enriched lineages have p-values < 0.0005 (shown in parentheses). N = 62 indicates the number of cell lines plotted in melanoma lineage. N = 70 indicates the number of cell lines plotted in skin lineage

B. In LSM2, the gene effect scores for eight melanoma cell lines in the Expression 22Q2 public dataset. The gene effect score of LSM2 in the A2058 (7.0911), A375 (5.8084), MeWo (5.8329), SKMEL-2 (5.4349), SKMEL-28 (5.6633), SKMEL-24 (6.0824), SKMEL-30 (7.0297), and SKMEL-1(6.6871) cell lines were positive

C. RNAi screening of LSM2 in the melanoma cell lines. In LSM2, the A2058 (-0.5231), A375 (-0.9363), MeWo (-0.6314), and SKMEL-2 (-0.7581) cell lines had a score below-0.5 for the RNAi data

D. CRISPR-Cas9 screening of LSM2 in the melanoma cell lines. In the CRISP dataset, LSM2 gene effect scores for A2058 (-2.0791), A375 (-1.8848), SKMEL-2 (-2.1033), SKMEL-24 (-1.9768), and SKMEL-30 (-1.6849) cell lines were below the cut-off value (-0.5)

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BMC Medical Genomics

ISSN: 1755-8794

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