Fig. 8

Individuals with high expression of ZNF880 and patients with low expression of ZNF880 in GSE14333 verify the potential function of ZNF880. A: Expression of ZNF880 between High-ZNF880 group and Low-ZNF880 group. B, C: GSEA analysis based on cell type signature gene sets, representing the enrichment of highly expressed genes in the High-ZNF880 group and the Low-ZNF880 group, respectively. D, E: GSEA analysis based on oncogenic signature gene sets. G-M: Differential expression of centriole protein between High-ZNF880 group and Low-ZNF880 group. N-R: Differential expression of cell cycle-dependent kinase genes and suppressor genes between High-ZNF880 group and Low-ZNF880 group. S, T: Differential expression of potential proto-oncogenes REG1B and REG3A between High-ZNF880 group and Low-ZNF880 group. U: Western blot results of ZNF880, CDK1, and CENPM in fresh tumor tissues and adjacent normal tissues from 4 matched patients with colorectal cancer (CRC), with β-actin as a reference. T-prefix represents tumor tissue, while N-prefix represents normal tissue. (Figs. S1, S2, S3, S4) V: Quantitative analysis of the Western blot band intensity of ZNF880 and CDK1 in 3 matched pairs of tumor tissues and adjacent normal tissues from colorectal cancer (CRC) patients with differential expression of ZNF880