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Fig. 3 | BMC Medical Genomics

Fig. 3

From: Identification of necroptosis-related gene TRAF5 as potential target of diagnosing atherosclerosis and assessing its stability

Fig. 3

Necroptosis-related genes and their biological significance in atherosclerosis (AS) and construction of the AS diagnostic model and screening of necroptosis-related differentially expressed genes (NRDEGs) by least absolute shrinkage selection operator (LASSO) regression analysis. A Gene set enrichment analysis results for the activation of pathways in AS than in non-AS specimens. B Biological processes (BPs), molecular functions (MFs), and Kyoto Encyclopedia of Genes and Genomes pathways (www.kegg.jp/kegg/kegg1.html) associated with NRDEGs. C Tuning feature selection in the LASSO model. D Profiles of the LASSO regression coefficients. E Receiver operating characteristic (ROC) curves for assessing the diagnostic effectiveness of the LASSO model in GSE20129 (training set). F ROC curves for assessing the LASSO model's diagnostic performance in GSE43292 (testing set). G Box plots showing the 13 NRDEGs after screening by the LASSO method. (*p < 0.05; **p < 0.01; ***p < 0.001)

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BMC Medical Genomics

ISSN: 1755-8794

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