Table 2 Association of genetically predicted AD with T1D and T2D risk in complementary analyses
From: Mendelian randomization indicates that atopic dermatitis contributes to the occurrence of diabetes
Data Source | Outcome | SNPs, n | Methods | OR | 95% CI | P value |
|---|---|---|---|---|---|---|
Forgetta et al. | T1D | 17 | Weighted median | 1.11 | 0.92, 1.35 | 0.276 |
17 | Simple median | 1.17 | 0.96, 1.43 | 0.114 | ||
17 | MR-raps | 1.20 | 1.00, 1.43 | 0.045 | ||
17 | MR-PRESSO†| NA | NA | NA | ||
FinnGen | T1D | 19 | Weighted median | 1.11 | 0.93, 1.33 | 0.255 |
19 | Simple median | 1.15 | 0.96, 1.39 | 0.138 | ||
19 | MR-raps | 1.09 | 0.91, 1.30 | 0.340 | ||
19 | MR-PRESSO†| NA | NA | NA | ||
Mahajan et al. | T2D | 19 | Weighted median | 1.08 | 1.02, 1.14 | 0.011 |
19 | Simple median | 1.10 | 1.04, 1.16 | 0.001 | ||
19 | MR-raps | 1.07 | 1.01, 1.12 | 0.014 | ||
16 | MR-PRESSO‡ | 1.08 | 1.03, 1.13 | 0.007 | ||
Xue et al. | T2D | 16 | Weighted median | 1.09 | 1.01, 1.17 | 0.025 |
16 | Simple median | 1.09 | 1.01, 1.17 | 0.023 | ||
16 | MR-Raps | 1.08 | 1.02, 1.15 | 0.015 | ||
16 | MR-PRESSO†| NA | NA | NA |