Table 3 Assessing heterogeneity and horizontal pleiotropy by different methods
From: Mendelian randomization indicates that atopic dermatitis contributes to the occurrence of diabetes
Data Source | Outcome | Heterogeneity | Pleiotropy | ||||||
|---|---|---|---|---|---|---|---|---|---|
IVW | MR-Egger | MR-Egger | |||||||
Q/Q_df | Cochran’s Q P | I2 (%) | Q/Q_df | Cochran’s Q P | I2 (%) | Intercept | Intercept P | ||
Forgetta et al. | T1D | 31.53/16 | 0.012 | 49 | 29.26/15 | 0.015 | 49 | 0.025 | 0.297 |
FinnGen | T1D | 37.85/18 | 0.004 | 52 | 27.55/17 | 0.051 | 38 | 0.061 | 0.022 |
Mahajan et al. | T2D | 50.86/18 | < 0.001 | 65 | 50.76/17 | < 0.001 | 67 | -0.001 | 0.859 |
Xue et al. | T2D | 21.26/15 | 0.129 | 29 | 21.07/14 | 0.100 | 34 | -0.005 | 0.73 |