Fig. 1

Clinical manifestations and pedigree of patients. a Pedigree of proband 1. Arrow represents the proband, square represents male, and circle represents female. b Palmoplantar keratoderma in proband 1 (P1). c-d Mild hyperkeratotic and erythematous plaques involve the palms and soles with scales. e Pedigree of proband 2, who was the only affected individual in a consanguineous family. f-h Yellow keratoderma and erythema involve dorsa of the hands and feet. Hyperhidrosis and maceration appear on the palms and soles