Evidence for causal effects of polycystic ovary syndrome on oxidative stress: a two-sample mendelian randomisation study

Table 2 Causal association between PCOS and various oxidative stress markers: based on IVW method

Oxidative stress markers	IVs (n SNPs)	Beta	SE	P	OR	95%CI
GST	13	0.007	0.076	0.932	1.007	0.867, 1.169
SOD	13	-0.015	0.068	0.828	0.985	0.863, 1.125
GPX	13	0.014	0.093	0.879	1.014	0.845, 1.218
CAT	13	0.004	0.068	0.958	1.004	0.879, 1.146
UA	13	1.105	0.748	0.140	3.018	0.696, 13.087
alpha-tocopherol	9	-0.022	0.016	0.188	0.979	0.948, 1.011
ascorbate	13	-0.013	0.015	0.397	0.987	0.959, 1.017
zinc	7	-0.008	0.096	0.934	0.992	0.821, 1.198
retinol	13	0.025	0.015	0.102	1.025	0.995, 1.056
albumin	13	0.020	0.012	0.093	1.020	0.997, 1.044
TBIL	13	-0.013	0.034	0.709	0.987	0.923, 1.056

PCOS, polycystic ovary syndrome; IVW, inverse variance weighting; SOD, superoxide dismutase; GST, glutathione S-transferase, GPX, glutathione peroxidase, CAT, catalase, UA, uric acid, TBIL, total bilirubin; SNP, Single Nucleotide polymorphisms; IVs, instrumental variables; OR, Odds ratio; CI, confidence interval; SE, standard error; n, number

ISSN: 1755-8794