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Table 3 Causal association between PCOS and oxidative stress markers: heterogeneity and pleiotropy

From: Evidence for causal effects of polycystic ovary syndrome on oxidative stress: a two-sample mendelian randomisation study

Oxidative stress markers

heterogeneity

   

pleiotropy

 
 

MR Egger

 

IVW

   
 

Q

P value

Q

P value

MR egger intercept

P value

GST

13.686

0.251

15.245

0.228

-0.045

0.287

SOD

7.163

0.786

9.034

0.700

0.050

0.199

GPX

21.564

0.028

22.815

0.029

0.041

0.441

CAT

10.531

0.483

11.337

0.500

-0.033

0.389

UA

32.404

0.001

33.727

0.001

0.275

0.516

Zinc

5.016

0.414

5.184

0.520

-0.021

0.699

alpha-tocopherol

1.113

0.993

1.116

0.997

0.000

0.960

ascorbate

10.554

0.481

11.025

0.527

-0.005

0.507

retinol

8.777

0.642

9.400

0.668

-0.006

0.447

albumin

13.207

0.280

13.374

0.342

0.002

0.716

TBIL

17.555

0.092

17.916

0.118

0.009

0.644

  1. PCOS, polycystic ovary syndrome; IVW, inverse variance weighting; SOD, superoxide dismutase; GST, glutathione S-transferase, GPX, glutathione peroxidase, CAT, catalase, UA, uric acid, TBIL, total bilirubin
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BMC Medical Genomics

ISSN: 1755-8794

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