Evidence for causal effects of polycystic ovary syndrome on oxidative stress: a two-sample mendelian randomisation study

Table 5 The associations between genetically predicted oxidative stress indices and the risk of PCOS.

Exposure	GWAS ID	Outcome*	n SNPs	Method	OR (95%CI)	P value
GST	prot-a-1283	PCOS	11	IVW	1.013(0.904–1.135)	0.824
			11	Weighted median	1.011(0.876–1.167)	0.880
			11	MR-Egger	1.024(0.797–1.316)	0.857
CAT	prot-a-367	PCOS	26	IVW	1.028(0.926–1.142)	0.601
			26	Weighted median	1.079(0.926–1.257)	0.330
			26	MR-Egger	1.303(0.919–1.849)	0.151
SOD	prot-a-2800	PCOS	23	IVW	1.050(0.936–1.178)	0.401
			23	Weighted median	1.010(0.860–1.187)	0.900
			23	MR-Egger	1.118(0.851–1.468)	0.431
GPX	prot-a-1265	PCOS	21	IVW	1.061(0.932–1.207)	0.371
			21	Weighted median	1.048(0.917–1.198)	0.492
			21	MR-Egger	1.044(0.811–1.344)	0.743
UA	ukb-d-30880_raw	PCOS	613	IVW	0.998(0.996–1.000)	0.115
			613	Weighted median	1.000(0.997–1.003)	0.964
			613	MR-Egger	1.000(0.996–1.003)	0.760
Tocopherol	met-a-571	PCOS	12	IVW	1.348(0.795–2.286)	0.268
			12	Weighted median	1.412(0.657–3.032)	0.377
			12	MR-Egger	3.74(1.297–10.783)	0.035^a
Zinc	ieu-a-1079	PCOS	11	IVW	1.102(0.967–1.257)	0.144
			11	Weighted median	1.100(0.932–1.300)	0.261
			11	MR-Egger	1.408(0.927–2.139)	0.143
Ascorbate	ukb-b-19390	PCOS	23	IVW	2.112(1.257–3.549)	0.005^b
			23	Weighted median	2.035(0.998–4.150)	0.051
			23	MR-Egger	1.846(0.474–7.184)	0.387
Retinol	ukb-b-17406	PCOS	19	IVW	0.852(0.410–1.769)	0.667
			19	Weighted median	1.031(0.441–2.411)	0.944
			19	MR-Egger	0.446(0.067–2.988)	0.417
Albumin	met-d-Albumin	PCOS	114	IVW	1.139(0.900–1.440)	0.279
			114	Weighted median	1.087(0.748–1.580)	0.660
			114	MR-Egger	0.951(0.581–1.556)	0.841
TBIL	ukb-d-30840_raw	PCOS	240	IVW	0.977(0.950–1.004)	0.096
			240	Weighted median	0.971(0.933–1.011)	0.156
			240	MR-Egger	0.970(0.939–1.001)	0.060

PCOS, polycystic ovary syndrome; GST, glutathione S-transferase; CAT, catalase; SOD, superoxide dismutase; GPX, glutathione peroxidase; UA, uric acid; TBIL, total bilirubin; SNP, single nucleotide polymorphism; GWAS, genome-wide association studies; ID, identity document; IVW, inverse variance weighted; n, number
^aP < 0.05, Tocopherol and PCOS have the causal effect according to MR-Egger method
^bP < 0.05, Ascorbate and PCOS have the causal effect according to IVW method
Selection of IVs related to exposures: independent SNPs (r² < 0.01 and distance > 250 kb); P value < 1 × 10^− 5; all the F statistics of the included SNPs were more than 10
*The source of PCOS GWAS is from the website-https://doi.org/10.17863/CAM.36024, Day, F. (2019). Summary statistics for PCOS. Apollo - University of Cambridge Repository

ISSN: 1755-8794