Evidence for causal effects of polycystic ovary syndrome on oxidative stress: a two-sample mendelian randomisation study

Table 6 The associations between genetically predicted characteristics indices of PCOS and the risk of oxidative stress

Exposure	GWAS ID	Outcome	GWAS ID	n SNPs	Method	OR (95%CI)	P value
T	ebi-a-GCST90012104	retinol	ukb-b-17406	92	IVW	0.929(0.872–0.990)	0.023
T	ebi-a-GCST90012114	UA	ukb-d-30880_raw	171	IVW	1.139e-5(4.415e-9–2.940e-2)	0.005
T	ebi-a-GCST90012114	TBIL	ukb-d-30840_raw	171	IVW	2.046(1.331–3.144)	0.001
LDL	ieu-b-110	retinol	ukb-b-17406	151	IVW	0.910(0.878–0.943)	2.726e-7
LDL	ieu-b-110	tocopherol	met-a-571	55	IVW	1.063(1.006–1.124)	0.031
LDL	ieu-b-110	GPX	prot-a-1265	164	IVW	1.181(1.015–1.375)	0.032
HDL	ieu-b-109	UA	ukb-d-30880_raw	340	IVW	0.000(1.542e-5–0.002)	2.843e-11
SHBG	ieu-b-4870	UA	ukb-d-30880_raw	187	IVW	7.079e-5(3.144e-6–0.002)	1.811e-9
SHBG	ieu-b-4871	UA	ukb-d-30880_raw	190	IVW	0.002(1.170e-4–0.042)	4.563e-5
SHBG	ieu-b-4871	albumin	met-d-Albumin	191	IVW	1.069(1.005–1.137)	0.033
BMI	ukb-b-19953	UA	ukb-d-30880_raw	441	IVW	1.303e9(4.571e + 7–3.713e + 10)	1.160e-34
BMI	ukb-b-19953	ascorbate	ukb-b-19390	440	IVW	0.938(0.905–0.971)	< 0.001
BMI	ukb-b-19953	retinol	ukb-b-17406	440	IVW	0.915(0.885–0.946)	1.271e-7
BMI	ukb-b-19953	albumin	met-d-Albumin	441	IVW	0.844(0.818–0.870)	2.910e-27
BMI	ukb-b-19953	TBIL	ukb-d-30840_raw	441	IVW	0.663(0.600–0.734)	1.623e-15
Waist-hip ratio	ieu-b-4830	GST	prot-a-1283	66	IVW	81.573(1.364–4.878e + 3)	0.035
TAG	ieu-b-4850	SOD	prot-a-2800	92	IVW	0.746(0.643–0.866)	0.001
TAG	ieu-b-4850	GPX	prot-a-1265	92	IVW	1.248(1.075–1.447)	0.004
Age at menarche	ieu-b-4822	CAT	prot-a-367	50	IVW	1.113(1.001–1.239)	0.048
Age at menarche	ieu-b-4822	UA	ukb-d-30880_raw	50	IVW	0.215(0.063–0.727)	0.013
Age at menarche	ieu-b-4822	albumin	met-d-Albumin	50	IVW	1.021(1.002–1.041)	0.030

PCOS, polycystic ovary syndrome; T, testosterone; LDL, low-density lipoprotein; HDL, high-density lipoprotein; SHBG, sex hormone-binding globulin; BMI, body mass index; TAG, triacylglycerol; GST, glutathione S-transferase; CAT, catalase; SOD, superoxide dismutase; GPX, glutathione peroxidase; UA, uric acid; TBIL, total bilirubin; SNP, single nucleotide polymorphism; GWAS, genome-wide association studies; ID, identity document; IVW, inverse variance weighted; n, number

ISSN: 1755-8794