Fig. 6
From: Differential expression of the circadian clock network correlates with tumour progression in gliomas
Progression patterns in mutated COSMIC genes in LGG and GBM. (A) Progression patterns in mutated COSMIC genes in LGG. (B) Progression patterns in mutated COSMIC genes in GBM. In (A) and (B), losses are shown in blue and mutation events (SSMs) in green. The percentage in each circle indicates the proportion of samples in which the event occurred, with the associated number of samples in parentheses. The size of the node indicates the relative frequency of the event in the dataset. The clock icon indicates a COSMIC gene which is part of the genes of interest. Dashed lines indicate edges for which one of three edge confidence measures had a p-value > 0.01. In (A), the hypergeometric test p-value for TP53 and PTPRD edge is 0.06. Temporal priority between MGMT and PTPRD is 0.08, between PTPRD and IRS4 0.31, between AKT3 and H3F3A 0.13, between LARP4B and LZTR1 0.46 and between LZTR1 and APC 0.46. In temporal priority between CDKN2C and IRS4 is 0.38