Table 1 Summary of up and down-regulation of 22 proteins shared between COPD, asthma, IPF and MLD

Actin, cytoplasmic 1

ACTB

Up (11)

Down (6)

Up (2)

Down (5)

Up (8)

Down (3)

Up (2)

Down (2)

Alpha-2-HS-glycoprotein

AHSG

Up (2)

Up (1)

Down (1)

Up (1)

Down (1)

Unknown

Albumin

ALB

Up (11)

Down (4)

Up (6)

Down (3)

Up (4)

Down (4)

Up (2)

Apolipoprotein A-I

APOA1

Up (4)

Down (1)

Up (3)

Up (3)

Down (3)

Unknown

Apolipoprotein C-III

APOC3

Up (2)

Up (2)

Down (3)

Unknown

Complement C3

C3

Up (6)

Down (3)

Up (2)

Down (6)

Up (2)

Down (10)

Down (2)

Ferritin heavy chain

FTH1

Up (Unknown)

Down (2)

Up (2)

Down (1)

Glyceraldehyde-3-phosphate dehydrogenase

GAPDH

Up (3)

Down (4)

Up (2)

Down (3)

Up (5)

Down (2)

Up (1)

Vitamin D-binding protein

GC

Up (2)

Down (1)

Up (3)

Down (4)

Up (1)

Up (3)

Glutathione S-transferase P

GSTP1

Up (2)

Down (5)

Up (1)

Down (5)

Up (0.3)

Down (4)

Not changed

Haptoglobin

HP

Up (10)

Down (2)

Up (5)

Down (2)

Up (7)

Down (3)

Up (5)

Heat shock protein beta-1

HSPB1

Up (1)

Down (2)

Up (2)

Up (2)

Down (2)

Up (1)

Immunoglobulin kappa constant

IGKC

Up (6)

Down (1)

Up (1)

Up (4)

Up (1)

Keratin, type I cytoskeletal 10

KRT10

Up (1)

Down (3)

Up (1)

Up (1)

Down (1)

Up (1)

Keratin, type I cytoskeletal 9

KRT9

Up (2)

Down (2)

Up (1)

Down (1)

Up (1)

Lipocalin-1

LCN1

Up (2)

Down (1)

Down (2)

Down (1)

Down (1)

Proteasome subunit alpha type-2

PSMA2

Up (1)

Down (1)

Up (1)

Down (2)

Down (1)

Retinol-binding protein 4

RBP4

Up (1)

Down (2)

Down (2)

Up (3)

Down (2)

Unknown

Protein S100-A8

S100A8

Up (8)

Up (4)

Down (2)

Up (2)

Up (2)

Protein S100-A9

S100A9

Up (6)

Down (3)

Up (5)

Down (Unknown)

Up (3)

Down (1)

Up (1)

Serotransferrin

TF

Up (2)

Up (1)

Down (4)

Up (3)

Down (2)

Down (1)

Ubiquitin-conjugating enzyme E2 N

UBE2N

Up (3)

Down (2)

Up (2)

Down (1)

Down (1)