Table 2 Some top biological and Reactome pathway between diseases
Asthma-IPF-MLD | |||||
Biological Process | P-value | Bonferroni method | Reactome Pathway | P-value | Bonferroni method |
Neutrophil degranulation | 1.9E-07 | 0.00233 | Neutrophil degranulation | 5.49E-06 | 0.013788 |
Retina homeostasis | 1.72E-11 | 2.11E-07 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | 6.53E-06 | 0.016399 |
Post-translational protein modification | 6.4E-06 | 0.078357 | Post-translational protein phosphorylation | 3.16E-06 | 0.007939 |
Cellular protein metabolic process | 1.71E-06 | 0.021 | Platelet degranulation | 0.000161 | 0.403806 |
COPD-Asthma-IPF | |||||
Biological Process | P-value | Bonferroni method | Reactome Pathway | P-value | Bonferroni method |
Neutrophil degranulation | 3.1E-66 | 3.79E-62 | Neutrophil degranulation | 1.52E-50 | 3.83E-47 |
Signal transduction | 1.74E-13 | 2.13E-09 | Platelet degranulation | 6.24E-41 | 1.57E-37 |
Innate immune response | 5.05E-18 | 6.18E-14 | Regulation of insulin-like growth factor (IGF) transport and uptake by insulin-like growth factor binding proteins (IGFBPs) | 8.41E-23 | 2.11E-19 |
Cell adhesion | 3.25E-18 | 3.98E-14 | Post-translational protein phosphorylation | 9.12E-17 | 2.29E-13 |
COPD-Asthma-MLD | |||||
Biological Process | P-value | Bonferroni method | Reactome Pathway | P-value | Bonferroni method |
Neutrophil degranulation | 1.9E-07 | 0.00233 | Neutrophil degranulation | 5.49E-06 | 0.013788 |
Post-translational protein modification | 6.4E-06 | 0.078357 | Regulation of insulin-like growth factor (IGF) transport and uptake by insulin-like growth factor binding proteins (IGFBPs | 6.53E-06 | 0.016399 |
Retina homeostasis | 1.72E-11 | 2.11E-07 | HDL remodeling | 3.88E-09 | 9.76E-06 |
Cellular protein metabolic process | 1.71E-06 | 0.021 | Retinoid metabolism and transport | 2.39E-06 | 0.005999 |
COPD-IPF-MLD | |||||
Biological Process | P-value | Bonferroni method | Reactome Pathway | P-value | Bonferroni method |
Neutrophil degranulation | 4.45E-10 | 5.45E-06 | Neutrophil degranulation | 4.7E-08 | 0.000118 |
Retina homeostasis | 2.11E-16 | 2.58E-12 | Post-translational protein phosphorylation | 1.74E-06 | 0.004372 |
Cellular protein metabolic process | 3.93E-08 | 0.000481 | Regulation of insulin-like growth factor (IGF) transport, and uptake by insulin-like growth factor binding proteins (IGFBPs) | 4.12E-06 | 0.010344 |
Post-translational protein modification | 1.13E-05 | 0.138488 | Retinoid metabolism and transport | 4.01E-07 | 0.001007 |