Fig. 1

The distribution of differential DNA methylation. a Circus plot showing CpGs. The chromosomes are arranged clockwise in the outermost circle, excluding the X and Y chromosomes. Genes marked green and red correspond to the top 8 hypomethylated and hypermethylated genes, respectively. The heat maps of the differentially methylated CGs are shown in the two innermost circles. b Bar chart of differentially methylated CpGs in each genomic region. c Manhattan plot displaying epigenome-wide association results, and -log₁₀ (p-value) was labeled with the yellow line