Table 1 Nine candidate chemicals for OA treatment predicted by CMap analysis
From: Osteoarthritis related epigenetic variations in miRNA expression and DNA methylation
Drug name | Score | Description | Target |
|---|---|---|---|
vemurafenib | -96.86 | RAF inhibitor | BRAF, CYP2C19, CYP3A4, CYP3A5, RAF1 |
ISOX | -96.65 | HDAC inhibitor | HDAC6 |
memantine | -95.35 | Glutamate receptor antagonist | GRIN1, CHRFAM7A, CYP2E1, DRD2, GRIN2A, GRIN2B, GRIN3A, HTR3A |
azacitidine | -95.24 | DNA methyltransferase inhibitor | DNMT1 |
hydrocortisone | -95.17 | Glucocorticoid receptor agonist | ANXA1, NOS2, NR3C1, NR3C2 |
beclometasone | -94.67 | Glucocorticoid receptor agonist | NR3C1, CYP3A5, GPR97, SERPINA6 |
RS-102895 | -94.01 | CCR antagonist | CCR2 |
flunisolide | -93.92 | Cytochrome P450 inhibitor | NR3C1 |
CP466722 | -93.91 | ATM kinase inhibitor | ATM |