Table 2 Comparison of the distribution of high (a) PRS (defined as PRS percentile > 80%). Coronary artery disease (CAD), type 2 diabetes (T2D), European (EUR), South Asian (SAS), Adjusted (a) polygenic risk scores (PRS)
Ancestry correction | EUR samples with High PRS | SAS samples with High PRS | |
|---|---|---|---|
T2D | PRS | 83,955 (18.5%) | 8331 (96.2%) |
adjusted PRS (aPRS) | 90,627 (20%) | 1659 (19.2%) | |
CAD | PRS | 89,438 (19.8%) | 2,848 (32.9%) |
adjusted PRS (aPRS) | 90,440 (20%) | 1,846 (21.3%) | |
Obesity | PRS | 85,853 (19%) | 6433 (74.3%) |
adjusted PRS (aPRS) | 90,794 (20.1%) | 1492 (17.2%) |