Fig. 2From: Proto-oncogene mutations in middle ear cholesteatoma contribute to its pathogenesisDomain graph for NOTCH1 and MYC with locations of the detected variants One variant (p.I471T) was located in the 11th and 12th EGF repeat domains, while one (p.C1505R) was located in the LNR domain. EGF repeat and LNR domains were functionally significant in NOTCH1, and therefore, mutations in these domains could result in loss of NOTCH1 functionBack to article page