Table 1 Descriptive statistics for demographic and reproductive characteristics of women included as cases and controls in GWAS of VMS phenotypes

Age

14,261

56.08 (7.37)

77,767

60.55 (5.39)

 < 1E-50

72,622

61.82 (5.09)

80,686

59.6 (5.81)

 < 1E-50

Body mass index

14,209

27.25 (5.03)

77,489

27.31 (5.11)

0.20

72,371

27.04 (4.81)

80,417

27.00 (5.16)

0.15

Age at menarche

13,832

12.95 (1.6)

75,335

12.93 (1.57)

0.36

70,614

12.94 (1.57)

78,102

12.94 (1.54)

0.63

Age at natural menopause

4,956

50.17 (4)

42,920

50.47 (3.91)

3.0E-07

33,250

49.53 (4.33)

72,629

50.7 (3.74)

 < 1E-50

Number of births

14,253

1.80 (1.15)

77,719

1.90 (1.16)

4.0E-21

72,583

1.91 (1.14)

80,640

1.85 (1.18)

7.0E-23

Number of pregnancies

13,977

2.31 (1.56)

76,437

2.34 (1.54)

0.018

71,437

2.39 (1.54)

79,382

2.29 (1.55)

3.9E-32

Townsend deprivation index

14,241

-1.51 (2.9)

77,673

-1.57 (2.89)

0.022

72,544

-1.57 (2.91)

80,607

-1.62 (2.87)

6.6E-04

Smoking status

14,087

76,901

5.4E-27

71,709

79,915

 - Never

56.2% (7,912)

58.6% (45,057)

53.1% (38,102)

61.8% (49,351)

 - Previous

33.8% (4,768)

34.1% (26,208)

38.8% (27,845)

31.3% (25,023)

 - Current

10.0% (1,407)

7.3% (5,636)

8.0% (5,762)

6.9% (5,541)

Vasomotor symptoms

14,261

77,767

33,015

16.8% (5,533)

36,106

7.5% (2,717)

 < 1E-50^*

Ever taken HRT

8,250

67.1% (5,533)

60,871

45.1% (27,482)

 < 1E-50^*

72,622

80,686

Used HRT before 2002

6,779

59.9% (4,062)

55,748

40.1% (22,359)

 < 1E-50

57,740

80,686

Used HRT after 2002

3,625

25.0% (908)

35,304

5.4% (1,915)

 < 1E-50

6,640

80,686