Table 5 Pathway enrichment for gene markers by SHAP
ID | Description | Observed gene count | Background gene count | Strength | FDR | Matched genes |
|---|---|---|---|---|---|---|
Gene Ontology (GO) Biological Process | ||||||
GO:0051282 | Regulation of sequestering of calcium ion | 5 | 134 | 1.63 | 0.0012 | ITPR1,PLCB1,DMD,ITPR2,RYR3 |
GO:0051209 | Release of sequestered calcium ion into cytosol | 4 | 61 | 1.88 | 0.0016 | ITPR1,PLCB1,ITPR2,RYR3 |
GO:0044057 | Regulation of system process | 6 | 592 | 1.07 | 0.0135 | ITPR1,EPB41,DMD,PRKG1,ITPR2,RYR3 |
GO:0019722 | Calcium-mediated signaling | 4 | 165 | 1.45 | 0.0167 | ITPR1,DMD,ITPR2,RYR3 |
GO:0019932 | Second-messenger-mediated signaling | 5 | 354 | 1.21 | 0.0167 | ITPR1,DMD,PRKG1,ITPR2,RYR3 |
GO:1,903,779 | Regulation of cardiac conduction | 3 | 68 | 1.71 | 0.0359 | ITPR1,ITPR2,RYR3 |
GO Molecular Functions | ||||||
GO:0015278 | Calcium-release channel activity | 3 | 17 | 2.31 | 0.002 | ITPR1,ITPR2,RYR3 |
GO:0099094 | Ligand-gated cation channel activity | 4 | 101 | 1.66 | 0.0023 | ITPR1,GRIK3,ITPR2,RYR3 |
GO:0005220 | Inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity | 2 | 3 | 2.88 | 0.0033 | ITPR1,ITPR2 |
GO:0035091 | Phosphatidylinositol binding | 4 | 252 | 1.26 | 0.024 | ITPR1,PLCB1,EPB41,ITPR2 |
GO:0070679 | Inositol 1,4,5 trisphosphate binding | 2 | 13 | 2.25 | 0.0266 | ITPR1,ITPR2 |
KEGG Pathways | ||||||
hsa04970 | Salivary secretion | 5 | 89 | 1.81 | 4.55E-06 | ITPR1,PLCB1,PRKG1,ITPR2,RYR3 |
hsa04730 | Long-term depression | 4 | 59 | 1.89 | 3.77E-05 | ITPR1,PLCB1,PRKG1,ITPR2 |
hsa04540 | Gap junction | 4 | 87 | 1.72 | 0.00011 | ITPR1,PLCB1,PRKG1,ITPR2 |
hsa04713 | Circadian entrainment | 4 | 92 | 1.7 | 0.00011 | ITPR1,PLCB1,PRKG1,RYR3 |
hsa04724 | Glutamatergic synapse | 4 | 111 | 1.62 | 0.00017 | ITPR1,PLCB1,GRIK3,ITPR2 |
hsa04611 | Platelet activation | 4 | 122 | 1.58 | 0.0002 | ITPR1,PLCB1,PRKG1,ITPR2 |
hsa04270 | Vascular smooth muscle contraction | 4 | 133 | 1.54 | 0.00023 | ITPR1,PLCB1,PRKG1,ITPR2 |
hsa04371 | Apelin signaling pathway | 4 | 131 | 1.55 | 0.00023 | ITPR1,PLCB1,ITPR2,RYR3 |
hsa04720 | Long-term potentiation | 3 | 64 | 1.73 | 0.00062 | ITPR1,PLCB1,ITPR2 |
hsa04924 | Renin secretion | 3 | 66 | 1.72 | 0.00062 | ITPR1,PLCB1,ITPR2 |
hsa04927 | Cortisol synthesis and secretion | 3 | 65 | 1.73 | 0.00062 | ITPR1,PLCB1,ITPR2 |
hsa04929 | GnRH secretion | 3 | 63 | 1.74 | 0.00062 | ITPR1,PLCB1,ITPR2 |
hsa04918 | Thyroid hormone synthesis | 3 | 74 | 1.67 | 0.00073 | ITPR1,PLCB1,ITPR2 |
hsa04971 | Gastric acid secretion | 3 | 73 | 1.67 | 0.00073 | ITPR1,PLCB1,ITPR2 |