Fig. 14

CCR7 regulates breast cancer cell migration and angiogenesis. A, B siCCR7 transfected MDA-MB-231 and MCF-7 cells, the effect of CCR7 on cell migration ability was assessed by scratch assay. C, D siCCR7 transfected MDA-MB-231 cells, the effect of CCR7 on tumour angiogenesis was assessed by angiogenesis assay. E siCCR7 transfected MDA-MB-231 and MCF-7 cells, the RNA expression levels of five prognostic genes were detected by PCR. F siCCR7 was transfected with MDA-MB-231 and MCF-7 cells, the effect of CCR7 on cellular activity was assessed by CCK8 assay. (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001)