Table 5 Occurrence of adverse events during NAC according to haplotypes

TG

89 (61.8)

CC

61 (36.8)

CG

3 (1.4)

Neutropenia

Grade < 2

Grade ≥ 2

 TG

14 (15.7)

75(84.3)

5.818

0.016

0.018

4.05(1.27–12.92)

 CC

14(22.9)

47(77.1)

0.892

0.345

0.413

0.65(0.23–1.83)

 CG

1(33.3)

2(66.7)

0.355

0.551

0.393

0.33(0.03–4.23)

Leukopenia

Grade < 2

Grade ≥ 2

 TG

16(18.0)

73(82.0)

6.892

0.009

0.013

4.26(1.36–13.30)

 CC

15(24.6)

46(75.4)

0.312

0.577

0.404

0.65(0.24–1.77)

 CG

1(33.3)

2(66.7)

0.202

0.541

0.605

0.51(0.34–6.56)

Peripheral neuropathy

Grade < 2

Grade ≥ 2

 TG

58(65.2)

31(34.8)

1.992

0.158

0.142

0.43(0.14–1.32)

 CC

37(60.7)

24(39.3)

0.158

0.691

0.512

1.34(0.56–3.21)

 CG

1(33.3)

2(66.7)

1.100

0.294

0.371

3.18(0.25–40.30)

AST increased

Grade < 1

Grade ≥ 1

 TG

48 (53.9)

41(46.1)

0.271

0.603

0.411

0.63(0.21–1.89)

 CC

30(49.2)

31(50.8)

0.768

0.381

0.596

1.25(0.55–2.88)

 CG

2(66.7)

1(33.3)

0.237

0.626

0.602

0.51(0.39–6.59)