Table 6 Association between SNPs and pre-therapeutic serum GGT level
Genotypes | Serum GGT level N (%) | pA | pB | OR(95%CI) C | |
|---|---|---|---|---|---|
Low level < 29 U/L | High level ≥ 29U/L | ||||
rs8135987 (T > C) | |||||
 TT | 60(52.6) | 9(31.0) |  |  |  |
 TC | 43(37.7) | 15(51.7) | 0.073 | 0.019 | 2.20(1.25–12.62) |
 CC | 11(9.7) | 5(17.3) | 0.127 | 0.351 | 3.97(0.41–11.59) |
 TT vs. TC + CC |  |  | 0.060 | 0.036 | 3.11(1.07–9.02) |
 TT + TC vs. CC |  |  | 0.319 | 0.791 | 1.22(0.27–5.45) |
 TT + CC vs. TC |  |  | 0.170 | 0.050 | 2.76(0.99–7.61) |
rs5751901 (T > C) | |||||
 TT | 49(43.0) | 8(27.6) |  |  |  |
 TC | 50(43.9) | 12(41.4) | 0.472 | 0.497 | 1.48(0.47–4.64) |
 CC | 15(13.1) | 9(31.0) | 0.034 | 0.068 | 3.32(0.91–12.13) |
 TT vs. TC + CC |  |  | 0.144 | 0.262 | 1.79(0.65–4.98) |
 TT + TC vs. CC |  |  | 0.028 | 0.067 | 2.78(0.93–8.29) |
 TT + CC vs. TC |  |  | 0.810 | 0.714 | 0.84(0.32–2.17) |
rs2017869 (G > C) | |||||
 GG | 50(43.8) | 9(31.0) |  |  |  |
 GC | 50(43.8) | 11(38.0) | 0.808 | 0.825 | 3.32(0.93–11.91) |
 CC | 14(12.4) | 9(31.0) | 0.035 | 0.065 | 1.14(0.36–3.54) |
 GG vs. GC + CC |  |  | 0.291 | 0.442 | 1.47(0.54–3.96) |
 GG + GC vs. CC |  |  | 0.022 | 0.046 | 3.09(1.02–9.36) |
 GG + CC vs. GC |  |  | 0.564 | 0.411 | 0.67(0.25–1.76) |
Haplotype | |||||
 TG |  |  | 0.059 | 0.157 | 0.44(0.14–1.37) |
 CC |  |  | 0.361 | 0.477 | 1.44(0.53–3.95) |
 CG |  |  | 0.570 | 0.677 | 1.74(0.13–23.40) |