Fig. 10

Post-transcriptional mechanisms underlying the IRscore and pan-cancer analysis of immunological features and prognostic relevance. A Differences in miRNA-targeted signaling pathways in TCGA-KIRC dataset between low and high IRscore groups. Red dots denote miRNA-targeted mRNAs that are up-regulated in high IRscore group, while blue dots denote miRNA-targeted that are down-regulated in high IRscore group. The circles represent signaling pathways enriched by targeted mRNAs. Red lines indicate up-regulated miRNAs in high IRscore group, while blue lines indicate down-regulated miRNAs in high IRscore group. B, C Bubble diagram illustrates the associations of IRscore with the abundance of immune and stromal cells and the activity of known biological processes across pan-cancer. D Differences in IRscore between tumors and normal tissues for each cancer type. E-M K-M curves of OS between low and high IRscore groups in different cancer types