Fig. 3

Validation of the high reproducibility of the inflammatory response classification in multiple datasets. A, B Up- and down-regulated biomarkers of each inflammatory response subtype. C Activity of KEGG pathways based on biomarkers. D SubMap analysis proves the similarities in inflammatory response subtypes between TCGA-KIRC and E-MATB-1980 datasets. E SubMap analysis proves the similarities in inflammatory response subtypes between TCGA-KIRC and ICGC datasets. F-I Transcriptome profiling of the template features across inflammatory response subtypes in the E-MATB-1980, ICGC, IMvigor210 and Liu et al. datasets. J, K K-M curves of OS among subtypes in the E-MATB-1980, and ICGC datasets. L-O Validation of transcriptional levels of immune checkpoints, abundance of immune and stromal cells, and immune and stromal scores across subtypes in the E-MATB-1980, ICGC, IMvigor210 and Liu et al. datasets