Fig. 6

Generation and verification of an inflammatory response-based scoring system for ccRCC. A, B LASSO Cox regression analysis for selecting the most robust prognostic inflammatory response-related genes. C An ensemble of identified eight genes with individual LASSO coefficients. D Distribution of IRscore, survival time, and mRNA expression of each gene in TCGA-KIRC dataset. E PCA plots visualize the dissimilarity of low and high IRscore groups in TCGA-KIRC dataset. F K-M curves of OS between groups in TCGA-KIRC dataset. G Validation of distribution of IRscore, survival time, and mRNA expression of each gene in the E-MATB-1980 dataset. H Validation of the dissimilarity of low and high IRscore groups in the E-MATB-1980 dataset. I Validation of the OS difference between groups in the E-MATB-1980 dataset. J, K ROC curves demonstrate the accuracy of OS prediction in TCGA-KIRC and E-MATB-1980 datasets