Table 1 The differences in mutational frequencies among the three inflammatory response subtypes
Mutated gene | TMB | IR1 | IR2 | IR3 | P | Adjusted p |
|---|---|---|---|---|---|---|
BAP1 | 34 (10%) | 13 (18.1%) | 17 (8.0%) | 4 (8.9%) | 5.53E-02 | 1.52E-01 |
VHL | 155 (47%) | 30 (41.7%) | 113 (53.1%) | 12 (26.7%) | 2.97E-03 | 1.63E-02 |
DST | 25 (8%) | 6 (8.3%) | 14 (6.6%) | 5 (11.1%) | 5.02E-01 | 7.30E-01 |
SETD2 | 39 (12%) | 8 (11.1%) | 24 (11.3%) | 7 (15.6%) | 6.73E-01 | 8.23E-01 |
MUC16 | 23 (7%) | 7 (9.7%) | 14 (6.6%) | 2 (4.4%) | 5.31E-01 | 7.30E-01 |
DNAH9 | 17 (5%) | 3 (4.2%) | 11 (5.2%) | 3 (6.7%) | 8.68E-01 | 8.68E-01 |
LRP2 | 17 (5%) | 3 (4.2%) | 11 (5.2%) | 3 (6.7%) | 8.68E-01 | 8.68E-01 |
KDM5C | 18 (6%) | 2 (2.8%) | 12 (5.6%) | 4 (8.9%) | 3.61E-01 | 7.30E-01 |
PBRM1 | 134 (41%) | 20 (27.8%) | 104 (48.8%) | 10 (22.2%) | 1.64E-04 | 1.80E-03 |
MTOR | 23 (7%) | 5 (6.9%) | 11 (5.2%) | 7 (15.6%) | 5.33E-02 | 1.52E-01 |
TTN | 68 (21%) | 11 (15.3%) | 47 (22.1%) | 10 (22.2%) | 4.68E-01 | 7.30E-01 |