Fig. 2

Forest Plot of Associations of blood lipids on Risk of psychiatric disorders. Abbreviations: LDL-C, Low density lipoprotein cholesterol; HDL-C, High density lipoprotein cholesterol; TC, Total cholesterol; TG, Triglycerides; MR, Mendelian randomization; IVW, inverse-variance weighted MR; CI, confidence interval; OR, odds ratio; MDD, Major Depressive Disorder; PTSD, Post-Traumatic Stress Disorder; AD, Alzheimer’s Disease. Results plotted are after pruning for instrument heterogeneity. The forest plot illustrates the OR of the impact of a 1-standard–deviation rise in genetically determined exposure (TC, HDL-C, LDL-C, TG) on outcome (psychiatric disorders) as a box, with error bars representing the 95% CI. The vertical dotted line delineates an OR of 1, i.e., no impact of the exposure on the result